The disruption of the vital enzymatic steps associated with glutamine utilization by glutaminase inhibitors results in reduced availability of metabolic intermediates required for nucleotide synthesis, tricarboxylic acid (TCA) cycle replenishment, and redox balance maintenance, collectively inducing metabolic stress and compromising cancer cell viability [56]
10.1016/j.det.2016.11.010 58 GuC.YangX.HuangL
Shin HR, Oh JK, Masuyer E, Curado MP, Bouvard V, Fang YY, Wiangnon S, Sripa B, Hong ST
OS negatively affects cell function mostly through the release of highly reactive oxygen species (ROS) within the cell environment(Bjrklund, Meguid, et al., 2020
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