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Small-molecule Inhibition of APT1 Affects Ras Localization and Signaling

The simulation indicated that amlodipine preferentially bound to amino acids, including proline (Pro)420, glutamic acid (Glu)424, serine (Ser)109, aspartic acid (Asp)111, arginine (Arg)458, Glu-125, alanine (Ala)510, threonine (Thr)514, Asp-517, Thr-518, lysine (Lys)114, histidine (His)145, Arg-185, leucine (Leu)115, Glu-182, and Thr-518

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Standard oral BPC-157 faces degradation by digestive enzymes, with estimates suggesting only about 3% reaches systemic circulation

Before using any peptide in a research model, consult the relevant institutional review board, animal-care committee, and biosafety office

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