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A deficiency in this vital nutrient can lead to a range of health issues, including fatigue, weakness, anaemia, and neurological problems

In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years

Typically, the positive effects last from about a week up to a month, though this can vary based on how your body absorbs and utilizes the vitamin, as well as your overall health