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Interestingly, some DAMs, such as L-tryptophan and sphingosine 1-phosphate, showed an evident negative correlation with changes in the level of TNF- and IL-17, while tightly positively correlating with altered concentrations of anti-inflammatory cytokines and chemokines, such as MIP-1 and RANTES

In particular, the Lys8, Trp207 and Lys210 residues showed structural differences from their corresponding residues compared with the oxidized and GSH-bound structures and rearrangement of these residues is related to the movements necessary for the interactions involved in AsA binding (Fig

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