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Advancements in miniaturized and portable devices, including lab-on-chip platforms and paper-based biosensors, could revolutionize in-field detection by enabling real-time, on-site monitoring

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However, it is important to note that erythrocytes generate ROS primarily as a result of (i) hemoglobin oxidation, which can be considered as an iron-mediated Fenton reaction, (ii) the activity of NAPDH oxidase and (iii) xanthine oxidoreductase, while in nucleated cells ROS are mainly generated in the mitochondrial electron transport chain

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