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Al-Kali A, Quints-Cardama A, Luthra R, Bueso-Ramos C, Pierce S, Kadia T, Borthakur G , Estrov Z, Jabbour E, Faderl S, Ravandi F, Cortes J, Tefferi A, Kantarjian H, Garcia-Manero G

doi: 10.1038/ng2091 189 ThorlaciusGEWahren-HerleniusMRonnblomL

Existing research poined towards significant macrophage infiltration in the tissues affected by HUA and its complications (5)

A 2024 network meta-analysis published in Metabolism , which reviewed 27 randomized controlled trials and over 15,500 patients with obesity or overweight, confirmed that GLP-1 receptor agonists produce significant weight loss and waist circumference reduction across multiple formulations

Approved as Wegovy (for weight loss) and Ozempic/Rybelsus (for type 2 diabetes)

Very strong correlation was established between GCLc and GR (0.974, p =0.005) and GS (0.935, p =0.020) expression and between GS and GR (0.886, p =0.045) expression levels (Table