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For hTYR, H161, H183, and H192 chelate CuA, while H344, H348, and H371 chelate CuB

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C.BuchnerP.LahnerB.DankuJ.et al (2008)

With the ease of administration, it also possesses the same advantages as sublingual therapy for patients and has been shown to be a preferred treatment modality to the IM route ( Subcutaneous B12 Subcutaneous B12 is occasionally used, especially in patients with inborn errors of cobalamin metabolism, who need high pharmacological doses of B12 to maintain their B12-dependent metabolic pathways and related biochemistry within normal range