Clin Sci 122:397407
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Unlike OCPs, which suppress the hypothalamicpituitaryovarian (HPO) axis pharmacologically, apigenin and ellagic acid modulate endocrine function physiologically, suggesting potential for safer long-term reproductive outcomes ( 14 Constraints of existing evidence Despite promising preclinical and early clinical findings, several limitations constrain the translation of apigenin and ellagic acid into mainstream PCOS therapy
However, BMDMs pretreated with P-Mn/TI@mHSA showed an obvious reduction in intracellular ROS fluorescence and decreased expression of pro-inflammatory cytokines, compared to untreated BMDMs or those pre-treated with other formulations
