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The metal chelating activity of flavonoids results either (i) in the formation of metal-chelates which have lower catalytic efficiency in Fenton reaction than pure flavonoids (decreased number of metal binding sites is usually associated with lower catalytic activity) or (ii) metal flavonoid chelates can intercalate into DNA of cancer cells, triggering cell death (Simunkova et al

However, this work once again highlights the remarkable metabolic plasticity of tumour cellsa key aspect of cancer biologywhich allows them to adapt to adverse nutritional conditions and, in many cases, to develop therapy resistance

and the GLP-1 drugs, semaglutide and tirzepatide

defined a double-negative feedback loop between EpCAM and the activated MAPK pathway

(PubMed) Diez-Ricote L, San-Cristobal R, Concejo MJ, et al

M., Parodi, G