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4.4.3 Anti-inflammatory effects in acute central nervous system injury After acute injuries such as stroke and trauma, the activation of microglia and the infiltration of peripheral immune cells into ischemic tissues may trigger a robust and deleterious neuroinflammatory response (261)

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One way in which Htt aggregates could cause toxicity is through depleting ubiquitin, a protein that binds to misfolded proteins to promote their clearance through the ubiquitin-proteasome system ( Notably, the N-terminal 17-residue domain stretch of huntingtin folds into an amphipathic -helix in the presence of membranes ( -helix formation at the N-terminus

P., Pan, A., Shin, K., & Lapalombella, R