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31 This cascade is crucial for cell proliferation, differentiation, and the synthesis of extracellular matrix proteins, essential for tissue repair and regeneration

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Epitalon research cited in support of sleep claims generally measures melatonin, a melatonin metabolite or clock-gene expression

Yet, we demonstrate that impaired Cl - extrusion underlies the failure of L838,417 to induce analgesia at high doses due to a resulting collapse in Cl - gradient, dramatically limiting the benzodiazepine therapeutic window