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The small molecule inhibitors or gene silencing of GLS1 expression has shown antitumor activity in a variety of cancers, including melanoma (Varghese et al., 2021), breast cancer (Gross et al., 2014), pancreatic cancer (Son et al., 2013), acute myeloid leukemia (Emadi et al., 2014), and malignant glioma (Yamashita et al., 2021)

Patients often experienced a reduction in waist circumference, which is a practical measure of abdominal fat changes

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Consequently, the suggested combination approach holds the promise of enabling the use of lower doses of conventional chemotherapy, thereby mitigating undesirable toxic effects

However, comparison of the H-site residues of GSTs displaying high activity with those having low activity does not identify a signature set of residues conferring the high rates of ketosteroid isomerization (Table 1)

Figure 3 Despite the clinical evidence for microbial infection in AD, other neurodegenerative diseases such as Parkinsons disease and ALS also are influenced by microbial infections and induction of inflammatory processes with microglial and astrocytic activation (Lotz et al., 2021), which would question the primacy of microbes in AD