Journal of Pharmaceutical Sciences
Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver
Fluid buildup in the lungs, which can result in shortness of breath and pain while breathing, or coughing up foamy mucus
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Note that sonication can cause solution warming and potential degradation
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