The accumulation of amyloid plaques is a pivotal factor associated with subsequent neuronal toxicity in AD pathogenesis, eventually associated with synaptic dysfunction and more severe cognitive deficits [38]
References Xie Y, Hou W, Song X, Yu Y, Huang J, Sun X, et al
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Target molecules, in comparison, have a much stronger affinity for the stationary phase, so in these steps only the non-target molecules should be washed away
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[DOI] [PubMed] [Google Scholar] 60.Zhao J., Brault J.J., Schild A., Cao P., Sandri M., Schiaffino S., Lecker S.H., Goldberg A.L