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Due to the complicating factor of a shot and the extra cost, it seems the best route for most people is to focus on getting adequate B vitamins from food, and supplement as necessary.

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Effects of l-carnitine supplementation on weight loss and body composition: A systematic review and meta-analysis

This can really help people with B12 deficiency live better lives

Some individuals report subjective improvement within days of initiating protocols

What this implies: if the vial remains sealed, in a cool, dry, dark place (ideally under refrigeration or freezing, with minimal humidity), you can reasonably expect 2-3 years of viability in the lyophilized state