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For consistency, reproducibility, and batch comparability, only the recommended diluent system should be used unless an alternative solvent is specifically stated in the product documentation

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ERK5 is a two-kinase transcription factor, and phosphorylation of ERK5 S496 directly inhibits NRF2 protein activity through SUMOylation modification at site 518, an inhibitory effect that can lead to inflammation and mitochondrial dysfunction in macrophages [133]