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In this study, compounds 23 , 24 , 25 , 76 , 78 , 79 , 80 , and 86 exhibit Log S (ESOL) values below 6.0, indicating very low water solubility (see the Supporting Information: File S1)

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Prevalence rates in multiple sclerosis increase with the patients latitude, and scientific studies have proven that colder climates are harsher for our immune and central nervous systems

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