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It is reasonable to hypothesize that NK2, another naturally occurring splicing variant of HGF, can bind c-MET via similar K1SEMA interaction, but cannot activate c-MET due to the lack of capability for dimerization (Fig

Khare E, Mishra J, Arora NK

However, Sterner et al reported JP-8 exposure decreased glutathione (GSH) levels in vitro, whereas other studies observed no changes in levels of GSH in vivo

doi: 10.3168/jds.S0022-0302(06)72391-8 77 LoerchS

Early compensatory changes in dopamine turnover, stemming from nigral cell degeneration, were shown to exacerbate oxidative stress and promote 4-HNE accumulation in the SN (87)

The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48