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Methods 12 , 943946 (2015)

Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study

NNMT catalyses the transfer of a methyl group from Sadenosylmethionine (SAM) to nicotinamide, producing 1methylnicotinamide and Sadenosylhomocysteine (SAH)

10.1111/j.1399-3054.2012.01696.x 64 KangasjrviS.NeukermansJ.LiS.AroE

Clarke CN, Lee MS, Wei W, Manyam G, Jiang ZQ, Lu Y, Morris J, Broom B, Menter D, Vilar-Sanchez E, Raghav K, Eng C, Chang GJ, Simon I, Bernards R, Overman M, Mills GB, Maru D, Kopetz S

doi: 10.1016/S1473-3099(11)70059-7