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Latvia Research suggests that senescent cells impair proteasome activity in the heart, leading to the accumulation of damaged proteins and reduced cardiac function

The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

Moreover, Se-polysaccharide purified from Pyracantha fortuneana , and Se-enriched sweet potato inhibited tumor growth via apoptosis pathway and decreased IL-2, TNF-, and VEGF in mice xenograft with human cancer tumor (93, 94)

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The skin benefit is promising according to your article and I will be documenting the results.

PMID: 31484368