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GLP-1 regulates appetite, slows digestion, and increases feelings of fullness, thereby promoting weight loss

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Additionally, -SMA + CAFs secret a range of cytokines, such as M-CSF, IL-6, IL-8, IL-10, TGF-, and CCL-2, inducing macrophage differentiation and M2 polarization that contributes to immunosuppressive TME [63,64,65]