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Mol Neurodegener 7:112

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Upon the upregulation and activation of Nrf2, the heterodimers of nuclear Nrf2 and small Maf proteins form to recognize antioxidant response elements (AREs), and then recruit key factors for transcription of Nrf2 target gene including HO-1 (Hayes et al., 2010)

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It reduces dark spots and dullness by suppressing melanin production