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In a 2025 review, after 1,200 mg intravenously twice a week for six weeks, 37.5% of participants reported lighter skin compared with 18.7% in the placebo group, and the effect faded after about six months

Protein S -glutathionylation is also suggested to play a role at the interface between changes in cellular redox state and hormonal signal transduction pathways under stress conditions

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Thanks to its antioxidant effects, many individuals have observed brighter, more even skin tones and improved texture over time

196 Stress exposure is a major pathogenic factor in disease models and can increase Ca 2+ -dependent release of ATP from neurons, which causes excitotoxicity