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Similar content being viewed by others Introduction Class I glutaredoxins (Grx) are glutathione-dependent thiol:disulfide oxidoreductases that reversibly convert a variety of low or high molecular weight disulfide substrates using the cysteinyl-containing tripeptide glutathione (GSH) as a reducing agent (EC 1.8.4.14) 1,2,3,4,5,6,7,8