Patella, F
Nature 649 , 487495 (2025)
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High insulin levels can have several downstream effects: Stimulating the ovaries to produce more androgens Disrupting normal ovulation Promoting fat storage, particularly around the abdomen Increasing long-term risk of metabolic conditions such as type 2 diabetes (4) Research suggests up to 7080% of women with PCOS have some degree of insulin resistance , even if they are not overweight (3,4)
As previously described 1 , the combination of drugs targeting distinct, non-overlapping pathways has proven effective in enhancing treatment efficacy
In the 2025 human IV infusion pilot, two adults receiving 10-20 mg doses showed no measurable changes in cardiac, hepatic, renal, thyroid, or glucose markers