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While p16 ink4a and SA--Gal are widely used in aging studies, emerging evidence suggests that p21 (a cyclin-dependent kinase inhibitor) may be a more robust marker of senescence in human kidney disease, particularly in contexts of chronic injury and fibrosis (Mylonas et al., 2021)
But they have limits: Orthotics support your arch but don't heal damaged tissue
CrossRef Resistin, TNF-, and microRNA 124-3p expressions in peripheral blood mononuclear cells are associated with diabetic nephropathy Amin Monjezi, Azam Khedri, Mehrnoosh Zakerkish, Ghorban Mohammadzadeh International Journal of Diabetes in Developing Countries.2022
Scientific understanding, particularly in the context of new gene data, indicates its profound regenerative and protective actions
PMID: 11605184
