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The program established a favorable safety profile but the Phase IIb endpoint did not differentiate sufficiently from placebo to support continued development for obesity

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Put a bandage over the injection site, if needed

For histological analysis, the femoral and tibial condyles were fixed in 10% neutral buffered formalin, decalcified with 20% EDTA, embedded in paraffin, and sectioned into 5-m thick frontal slices

Obesity is associated with a decreased lipolytic effect of catecholamines in adipose tissue (65)