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Plausible degradation pathways include: Serum aminopeptidases (cleaving from the N-terminus) Endopeptidases (internal bond cleavage) Hepatic uptake and degradation Renal clearance (though direct renal excretion of intact peptide of this size is typically limited) Whether BPC-157 generates active metabolites i.e., smaller peptide fragments that retain biological activity is not established in the public literature

doi: 10.3389/fcell.2024.1435125 Received 19 May 2024 Accepted 27 June 2024 Published 11 July 2024 Volume 12 - 2024 Edited by Takehito Ouchi, Tokyo Dental College, Japan Reviewed by Kui Xu, Anhui University of Chinese Medicine, China Xiaolei Li, University of Pennsylvania, United States Updates Copyright 2024 Zheng, Liu, Sun and Meng

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de Bari O, Wang HH, Portincasa P, Paik CN, Liu M, Wang DQ

Overall, 112 female participants received either the HCP ( n = 57) at 10 g per day or placebo ( n = 55) for 8 weeks

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