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Too much estrogen being metabolized through CYP1B1 into 4-OHE1(E2) and the estrogen quinones can potentially be bad if your body has slower phase II (COMT, GSTP1, GSTM1, NQO1) enzymes.[ref][ref] The connection between smoking and estrogen-related cancers: Smoking significantly increases the risk of breast cancer and prostate cancer

Melanin is particularly important for defending cryptococcal cells during infection, as it can scavenge harmful free radicals and protect cells from oxidative bursts during engulfment by host innate immune cells

Glutathione (GSH) is a cysteine-containing tripeptide, which is the most abundant nonprotein thiol in cells [4]

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M., Imbesi, R., & Castrogiovanni, P