(Source) When this enzyme is present in great concentration within fat cells and is highly expressed, obesity is inevitable: In the study by Kannt and colleagues, NNMT expression is increased ~2-fold in subcutaneous and omental adipose tissue of type 2 diabetic subjects (men and women), compared to healthy controls Importantly, interventions that increase insulin sensitivity, such as exercise and bariatric surgery, also decreased expression of NNMT in adipose tissue For this reason alone, scientists have been interested in every possible method for inhibiting NNMT expression: We report that NNMT expression is increased in [white adipose tissue (WAT)] and liver of obese and diabetic mice
Fundamentals of Pharmacology
Its considered an investigational compound in many places and is not universally approved for medical use, but it remains under research for weight-management applications
Keep it separate from food, and note the date you first opened any multi-dose vial
The study started on 6 February 2019, but recruitment was delayed due to the COVID-19 pandemic
Loving it