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ALS is characterized by aberrant buildup of mutant superoxide dismutase (SOD) 1 protein complexes (Quatorze et al.)

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Consistently, protein expression analyses demonstrated that sUA+LPS stimulus led to reduced VDAC expression in WT and Myd88 / macrophages, while Nlrp3 / macrophages displayed similar levels of VDAC protein to non-stimulated cells (Fig