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(2022, May 7)

Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

according to the National Academies of Sciences, Engineering, and Medicine, absorption is approximately 50% at 1 mcg but falls to roughly 1.3% at 1,000 mcg

Most users notice initial effects within 2-3 weeks, with visible skin changes becoming apparent at the 4-6 week mark