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Unlike apoptosis, paraptosis does not hinge on caspase activity but frequently hinges on the activation of mitogen-activated protein kinases (MAPKs), such as MAPK8/JNK, MAPK14/p38, and mitogen-activated protein kinase kinase 2 (MAP2K2/MEK2) [148]

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Unfortunately, glutathione levels decline with age, stress, and environmental exposure, leaving the body more vulnerable to oxidative damage

The stained sections were subsequently dehydrated through an ethanol series, cleared with xylene, and mounted using a resinous medium for microscopic analysis