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Furthermore, imatinib induces ferroptosis in GIST by upregulating STUB1, which promotes K191 site-specific ubiquitination and degradation of GPX4, thereby disrupting the antioxidant defense, triggering lipid peroxidation, and leading to iron accumulation
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10.1038/s41392-022-01257-8 50 WuX.WeiS.ChenM.LiJ.WeiY.ZhangJ.et al (2022b)
The activity of caspase-3 is not confined to neurological tissue