In animal studies spanning doses from nanograms to milligrams per kilogram, no lethal dose threshold (LD1) has been established - meaning a toxic dose was not identified in preclinical testing
These ROS activate a cascade of signaling pathways, further exacerbating the inflammatory response and leading to pancreatic tissue damage (111)
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It is therefore possible that oxidant stress reduces remethylation and enhances transsulfuration to maintain, via an autocorrective process, the intracellular glutathione pool, which would be essential for the redox-regulating capacity of cells
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