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Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H, Nagano O
95 While routine genetic testing for APOEe4 is not recommended at this time, health care professionals request APOEe4 testing for individuals considering the treatments lecanemab and donanemab, as people with the APOEe4 gene are at increased risk of side effects from the treatments
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The -C-P-Y-C- motif is found in the catalytic core of Grx1 and Grx2 (Liedgens et al., 2020
Furthermore, epidemiological and intervention research suggests that they may lower the risk of developing type 2 diabetes and cardiovascular disease (Clifford et al., 2020)
Some studies have proposed that inhibition of autophagy can affect the progression of OA by causing chondrocyte apoptosis through mitochondrial dysfunction, so the knockdown of the mTOR signaling pathway can improve the balance between synthesis and degradation of chondrocyte extracellular matrix in osseous joints (128)
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