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In placebo-controlled trials for type 2 diabetes mellitus, an injection site reaction (e.g., injection-site discomfort, erythema) was reported in 0.2% of patients receiving semaglutide

DES(1-3) IGF-1 is not separately enumerated on the WADA Prohibited List as of the 2026 iteration, although the WADA S2 category includes language covering "any substance with similar chemical structure or similar biological effect(s)," which would encompass IGF-1 analogues broadly