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The upregulation of p57 is essential for TGF-induced cell cycle arrest in these cells 48
The peptide is dispersed throughout the entire body, so the concentration reaching the specific bicep tear might be lower than with a direct, localized injection
In intact skin without a penetration enhancer (such as ethosomes, liposomes, or hyaluronic acid conjugation), multiple ex vivo tape-stripping studies show that most topically applied GHK-Cu accumulates in the stratum corneum and upper viable epidermis, not in the dermis where fibroblasts live
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