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While improvements are likely, temporary flare-ups can still occur

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Pramlintide differs from human amylin by only 3 proline substitutions

doi: 10.1007/s10620-018-4977-8

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This reversal was seen also on the background of the disturbed prostaglandins- and NO-systems, prostaglandins synthesis inhibition as well as NO-overstimulation (NOS-substrate L-arginine) or NO-blockade (N(G)-nitro-L-arginine methyl ester (L-NAME)) (Stupnisek et al., 2012