This protocol rapidly induced marked functional disability, in particular, a difficulty with maintaining body balance while rearing, an inability of the right forelimb to react (and thereby cuprizone-rats react only with one or no forelimb), and severely affected various brain areas [31]
Timing and Frequency Injections are done once daily before bed, at least two hours after the last meal
After that, many patients shift to monthly doses for maintenance
Chem 279 , 2440324413 (2004)
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