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The extra CBS enzyme causes homocysteine to be lost through the transsulfuration pathway.[ref] What about low homocysteine

As a result, the livers ability to produce the master antioxidant, glutathione, is reduced leading to oxidative damage, fatigue, and premature aging

Glutathione: Benefits and Supplements

Today 19 , 7987 (2014)

Even in cases where chemotherapy and/or radiotherapy are given post-operatively following surgical resection of solid tumors, recurrence occurs in up to 40% of patients (Predina et al., 2013)