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Funding The CREDENCE trial and this analysis were funded by Janssen Research & Development, LLC

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Hou Y, Wang S, Jiang L, Sun X, Li J, Wang N, et al

(2023) found that Hyp could enhance OAT1 expression through HNF-1 and PXR regulation, thereby improving OAT1 uptake capacity, lowering indoxyl sulfate accumulation in vivo , and facilitating its urinary elimination, consequently reducing Cis-induced AKI