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Here is the honest evidence status up front: the individual compounds have real human data Tesamorelin is an FDA-approved prescription drug (EGRIFTA) for HIV-associated lipodystrophy, and Ipamorelin has been characterized in human GH-release studies but the fixed Tesamorelin + Ipamorelin blend as sold for research has no completed human randomized controlled trial of its own

Whether the breadth translates to clinical benefit on intact human skin depends entirely on whether the molecule reaches the cells whose gene expression it modulates

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Despite the FDA's initial negative recommendation, I still predict they will pass