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FSP1 was the highest ranking gene that correlated with resistance to RSL3 ( P = 0.392), ML162 ( P = 0.424) and ML210 ( P = 0.398)

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However, significantly positive effects of the biotics intervention on other markers of renal function, such as eGFR, serum albumin, C-reactive protein, IAA levels, and lipid metabolites, were not observed (Liu et al., 2022)

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Validation of Bioanalytical Method The validation was executed as per Guidance for industry: Bioanalytical Method Validation from the United States Food and Drug Administration ( Selectivity The selectivity of the method was evaluated by analyzing blank plasma samples prior to spiking