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Notably, insulin-sensitizing therapies ( e.g ., metformin) have been shown to elevate SHBG levels in women with PCOS, establishing SHBG as a reliable biomarker for insulin resistance (86, 87)

To achieve this, a group of 64 young and aged rats were allocated into groups, all of which would receive either a low or high dose of caffeine or paraxanthine, respectively

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Similarly, the Volocity image analysis software allowed precise quantification of several histological variables, including collagen denaturation

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