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Approximately 5% of the inhaled O 2 is converted to reactive oxygen molecules with an unpaired number of electrons such as hydroxyl (OH), superoxide anion (O 2 -), hydrogen peroxide (H 2 O 2 ), oxygen singlet (O 2 ), hypochlorite (OCI-), nitric oxide (NO), and peroxynitrite (ONOO-) radicals

This work was supported by the National Health and Medical Research Council of Australia (NHMRC) Project grants (1006141, 10305133, 1086887, and 1095215)