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Zabludovsky, J

Vitamin E acts as a regulator of cellular metabolism, and its deficiency leads to anaemia, dysregulation of energy metabolism, irregular mitochondrial function, and tissue damage resulting from increased lipid peroxidation (170)

This severe glutathione deficit was accompanied by elevated ventricular lactate, a clear biomarker indicating that the brains of these patients are relying on highly inefficient, oxygen-deprived anaerobic metabolism due to mitochondrial stress

Fibroblasts are the most resistant cell type, protected by their low mitochondrial content and high expression of copper-buffering proteins, such as MTs [12]

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