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Melatonin interacts with its membrane receptors, activating cascades of intracellular signals that regulate the transcription factors of key enzymes that act in the processes of cancer development, altering DNA and generating changes in cancer cells and their microenvironment, reducing carcinogenic development [28,33]

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Mice and rats were anesthetized with subcutaneous ketamine/xylazine, the corneal surface was numbed with 0.5% proparacaine drops, and pupils were dilated with sequential drops of 0.5% tropicamide and 2.5% phenylephrine HCl