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Clinically, ALS presents itself as a progressive ascending paralysis and muscle atrophy leading ultimately to respiratory failure and death

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In certain embodiments, any otic formulation or composition described herein has less than about 60 colony forming units (CFU), has less than about 50 colony forming units, has less than about 40 colony forming units, has less than about 30 colony forming units of microbial agents per gram of formulation or composition

10.1111/mmi.13927