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The real therapeutic opportunity may lie in viewing neuronglia interactions as druggable units, rather than treating these cell types in isolation

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The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2/PAPP-A/IGFBP-4 axis

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It is an essential cofactor for many enzymes which require thiol-reducing equivalents, and helps to keep redox-sensitive active sites on enzymes in the necessary reduced state